NCLEX · Pharmacological Therapies

A client is receiving heparin infusion and the aPTT comes back at 120 seconds (therapeutic range 60-100 seconds for anticoagulation, normal 25-35 seconds). What is the appropriate nursing action?

Correct answer

Hold or reduce the heparin infusion per protocol and notify the provider — an aPTT of 120 seconds is above the therapeutic anticoagulation range, indicating excessive anticoagulant effect and increased bleeding risk

  1. A Document and reassess in 4 hours without action
  2. B Increase the heparin rate
  3. C Continue at the same rate
  4. D Hold or reduce the heparin infusion per protocol and notify the provider — an aPTT of 120 seconds is above the therapeutic anticoagulation range, indicating excessive anticoagulant effect and increased bleeding risk

Why this is the answer

HEPARIN MONITORING with aPTT:

Therapeutic range: For anticoagulation (treatment of VTE, PE, atrial fibrillation), aPTT target is typically 60-100 seconds (1.5-2.5× normal); this range varies by indication and institution protocol; SUPRATHERAPEUTIC (>100 seconds): Excessive anticoagulation — HIGH BLEEDING RISK.

Nursing actions: Hold or reduce the infusion per heparin protocol; notify RN and/or provider for orders; assess for bleeding (check IV sites, urine color, stool, neurological status, vital signs); anticipate order to repeat aPTT after adjustment; HEPARIN REVERSAL if major bleeding: protamine sulfate (antidote).

Monitoring frequency: aPTT checked every 6 hours until stable in therapeutic range, then every 12-24 hours.

Pn scope: Monitor aPTT results; identify values outside parameters; report to RN; implement protocol-driven adjustments per orders; never independently adjust heparin without an order or protocol.

Source: NCLEX-PN Test Plan: Physiological — Pharmacology, Heparin aPTT Monitoring

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About this topic: Pharmacological Therapies

Pharmacological therapies questions cover medication administration, dosage calculation, the rights of medication administration, common drug classes and their side effects, and when to hold a medication and report. This is one of 18 PN: Physiological Integrity questions on pharmacological therapies, each with a full explanation on a single study page.

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