NCLEX · Study Guide

NCLEX-RN HIV and Immunocompromised Patient Care — Practice Questions

HIV and immunocompromised patient nursing questions test infection control, medication adherence, and the specific opportunistic infections that determine nursing priorities. These questions build the knowledge framework for this consistently tested NCLEX topic.

HIV nursing questions test both the science (CD4 counts, viral load, opportunistic infections) and the clinical application (when to initiate which precautions, which symptoms require urgent assessment, medication adherence strategies).

CD4 count and infection risk: CD4 above 500 — relatively protected; CD4 200-500 — increased risk; CD4 below 200 — AIDS-defining threshold, high risk for Pneumocystis pneumonia (PCP); CD4 below 50 — extreme risk for CMV retinitis, MAC (Mycobacterium avium complex), toxoplasmosis.

Source

How these questions were selected

These 10 questions were curated by the 247SimpleTests Editorial Team from our RN: Safe and Effective Care Environment practice bank. Each was selected because it covers a concept that appears frequently on the real exam and that many candidates find difficult on their first attempt. The full practice test has 25 questions — work through all of them once you've reviewed this guide.

The questions

Question 1

Which is the safest action when receiving a verbal medication order from a physician?

  1. Write down the order without confirming
  2. Write down the order, then read it back to the physician for verification (read-back), and ensure the physician confirms the order is correct ✓
  3. Implement the order from memory
  4. Refuse all verbal orders
▶ Show full explanation

Verbal and telephone orders are error-prone because of misheard medications, similar-sounding drug names, and number confusion. The safest practice is the 'read-back' procedure: (1) The nurse writes down the order as it is given; (2) The nurse reads back the complete order to the physician — drug name, dose, route, frequency; (3) The physician confirms the order is correct before the call ends. This is required by The Joint Commission's National Patient Safety Goals for verbal/telephone orders. Some institutions have additional safeguards: spelling out high-alert medication names, having a second nurse listen, restricting verbal orders to emergencies. Verbal orders should be entered into the medical record promptly and signed by the physician within the time frame required by policy (usually 24 hours). The read-back applies to critical lab values as well — the recipient repeats the value to confirm.

Source: NCLEX-RN Test Plan, Medication Safety — Verbal Orders

Full Q&A page →

Question 2

A client has C. difficile (C. diff). Which precaution is most important for hand hygiene?

  1. Alcohol-based hand rub is sufficient
  2. Soap and water must be used because alcohol-based products do not kill C. difficile spores ✓
  3. Hand hygiene is not required
  4. Only at the start and end of the shift
▶ Show full explanation

Clostridioides difficile (C. diff) is unique among healthcare pathogens because it forms spores that are resistant to alcohol-based hand sanitizers. Alcohol does not kill C. diff spores. Hand hygiene after caring for C. diff clients (or any patient with suspected infectious diarrhea) must use soap and water, with vigorous mechanical washing to physically remove the spores. The CDC and WHO both specifically recommend this. Contact precautions are required for C. diff clients: gowns and gloves for room entry, dedicated equipment (BP cuffs, stethoscopes), private room or cohorting with other C. diff clients. Environmental cleaning requires sporicidal disinfectants (bleach or specific EPA-registered products) rather than standard quaternary ammonium disinfectants which do not kill spores. C. diff is one of the most common healthcare-associated infections and requires diligence to prevent transmission.

Source: NCLEX-RN Test Plan, Infection Control — C. difficile

Full Q&A page →

Question 3

Who has the authority to consent to medical treatment for an unconscious adult client without advance directives?

  1. Any family member who arrives first
  2. The legal next of kin or designated healthcare proxy, following the state's hierarchy of surrogate decision-makers — typically spouse, adult children, parents, adult siblings — or by court order if no surrogate is available ✓
  3. The hospital administrator
  4. Anyone present
▶ Show full explanation

When an adult client is unable to consent due to incapacity and has no advance directive identifying a healthcare proxy, state law establishes a hierarchy of surrogate decision-makers. The typical order: spouse, adult children, parents, adult siblings, other relatives, close friends, court-appointed guardian. The exact order varies by state. The surrogate decision-maker is expected to apply 'substituted judgment' — making the decision the client would have made if able. In an emergency where consent cannot be obtained and delay would be life-threatening, 'emergency consent' (implied consent) allows necessary treatment to proceed. For non-emergency situations where surrogates cannot agree or are unavailable, courts may appoint a guardian. Healthcare facilities have ethics committees that consult on complex consent situations. The nurse documents the consent process carefully, including who consented, their relationship, and the basis for their authority.

Source: NCLEX-RN Test Plan, Consent — Surrogate Decision-Makers

Full Q&A page →

Question 4

What is the first action a nurse should take when responding to a disaster or mass casualty event?

  1. Begin treating clients immediately based on order of arrival
  2. Triage clients using a standard system (e.g., START) to categorize based on severity and survivability, then treat in priority order ✓
  3. Wait for all clients to arrive
  4. Refer all clients elsewhere
▶ Show full explanation

Mass casualty events overwhelm normal resources and require triage — sorting clients to allocate limited care effectively. The START (Simple Triage and Rapid Treatment) system is widely used: clients are categorized in less than 60 seconds each into four groups identified by colored tags: Red (Immediate) — life-threatening injuries requiring immediate care to survive (severe bleeding, airway compromise); Yellow (Delayed) — serious injuries but stable, can wait for care; Green (Minor) — walking wounded, minor injuries; Black (Deceased/Expectant) — dead or so severely injured that survival is unlikely given resource constraints. The goal is greatest good for the greatest number. This contrasts with day-to-day triage where the most severely injured client receives the most aggressive care. Mass casualty triage requires accepting that some clients who might survive with full resources may be tagged black or yellow because resources cannot be diverted. Repeat triage occurs as conditions change.

Source: NCLEX-RN Test Plan, Emergency Response — Triage

Full Q&A page →

Question 5

What is HIPAA, and what does it require of nurses?

  1. A nursing licensing exam
  2. Federal law (Health Insurance Portability and Accountability Act) protecting patient health information; nurses must not share protected health information (PHI) without authorization except for treatment, payment, and healthcare operations ✓
  3. A type of insurance
  4. A workplace safety law
▶ Show full explanation

HIPAA (Health Insurance Portability and Accountability Act of 1996) Privacy Rule protects Protected Health Information (PHI) — any individually identifiable health information. Nurse responsibilities: (1) Access PHI only for legitimate work purposes; (2) Discuss PHI only in private settings with people authorized to know; (3) Do not share PHI on social media; (4) Verify identity before releasing information; (5) Protect physical and electronic records; (6) Report breaches per facility policy. PHI can be shared without specific authorization for treatment (other healthcare providers caring for the client), payment (billing), and healthcare operations (quality improvement, training). Family members do not automatically have access — the client can authorize them, and emergency situations have specific rules. Violations of HIPAA carry significant penalties: civil fines up to millions of dollars, criminal penalties up to imprisonment in severe cases, loss of nursing license, employment termination. State laws may provide additional protections beyond HIPAA.

Source: NCLEX-RN Test Plan, Legal — HIPAA

Full Q&A page →

Question 6

A nurse receives a verbal order from a physician by telephone. What is the correct procedure?

  1. Write the order and implement it without reading it back
  2. Repeat the order back to the physician completely (read-back), document it as a verbal order with the prescriber's name, date, time, and nurse's signature, then ensure the physician countersigns within the facility's required timeframe ✓
  3. Refuse to accept verbal orders under any circumstances
  4. Only accept verbal orders from attending physicians, never residents
▶ Show full explanation

VERBAL AND TELEPHONE ORDER SAFETY is a Joint Commission National Patient Safety Goal specifically because miscommunication of verbal orders is a leading cause of medication errors. THE REQUIRED PROCESS: (1) RECEIVE the order; write it down simultaneously; (2) READ BACK the complete order word-for-word to the prescriber; (3) RECEIVE CONFIRMATION that the read-back is correct ('that is correct'); (4) DOCUMENT: Record in the chart as a verbal order with the prescriber's name, date, time, the full order, and the receiving nurse's name/credentials; some facilities use 'V.O. Dr. Smith / T.O. (telephone order)' notation; (5) COUNTERSIGNATURE: The prescriber must sign (countersign) the order within the facility's policy timeframe — typically 24 hours for routine orders, immediately for emergencies in some facilities. WHY READ-BACK MATTERS: Common verbal communication errors include: sound-alike drug names (Celebrex/Celexa, Toradol/Tramadol); numbers (15 mg vs 50 mg sounds similar by phone); wrong patient (same-sounding names). The read-back gives the prescriber a chance to catch these errors before they reach the patient. WHEN VERBAL ORDERS ARE APPROPRIATE: Emergencies; situations where the prescriber cannot physically be present; after-hours phone calls. WHEN TO CLARIFY: If the order seems unusual, too high/low a dose, or potentially dangerous — the nurse has both a right and obligation to clarify before implementing.

Source: NCLEX-RN Test Plan: Safe Care — Verbal/Telephone Orders

Full Q&A page →

Question 7

A nurse is caring for a client who is confused and attempts to climb out of bed. Which restraint alternative should the nurse try FIRST?

  1. Apply wrist restraints immediately
  2. Try non-restraint alternatives first: reorientation, keeping the call light within reach, moving the client closer to the nursing station, asking a family member to stay, providing familiar objects, ensuring the environment is safe (bed in lowest position, side rails up), and addressing unmet needs (pain, need to void, hunger) ✓
  3. Sedate the client with a PRN benzodiazepine
  4. Restrain only the legs
▶ Show full explanation

RESTRAINT ALTERNATIVES must be exhausted before physical restraints are applied. Restraints are a last resort because they carry significant risks: increased agitation, aspiration, pressure injuries, psychological trauma, and death. JOINT COMMISSION and CMS standards require documentation that alternatives were tried. ALTERNATIVES TO RESTRAINTS: (1) REORIENTATION: Speak calmly and frequently; orient to place, time, and situation; explain what's happening; (2) ENVIRONMENT SAFETY: Bed in lowest position; side rails up (usually 2-3 rails, not all four — 4 rails = restraint in many states); remove items the confused client could harm themselves with; (3) CALL LIGHT: Ensure it's accessible and the client knows how to use it; (4) CLOSE MONITORING: Move the client closer to the nurses' station; increase check frequency; (5) ADDRESSING UNMET NEEDS: Pain (confusion often stems from inadequately managed pain); bladder (urge to void causes many fall attempts); hunger/thirst; sleep deprivation; (6) FAMILY PRESENCE: A familiar face and voice significantly reduces confusion-driven agitation; (7) ACTIVITY: Appropriate exercise during the day reduces nighttime restlessness; (8) REMOVE TRIGGERS: IV lines, catheters, tubes can be confused as irritants and removed — consider whether each can be covered, secured, or removed; (9) SITTERS: Trained patient companion who stays with client. IF RESTRAINTS ARE REQUIRED: Specific medical order required; must specify type, location, duration; reassess every 2 hours (release, reposition, toilet, circulation check); document continuously.

Source: NCLEX-RN Test Plan: Safe Care — Restraint Alternatives

Full Q&A page →

Question 8

Which of the following tasks can an RN appropriately delegate to a licensed practical nurse (LPN)?

  1. Performing an initial admission assessment on a newly admitted complex client
  2. Administering a scheduled oral medication to a stable client with no known allergies to that medication ✓
  3. Developing a nursing care plan for a newly diagnosed client
  4. Providing education to a client newly diagnosed with insulin-dependent diabetes
▶ Show full explanation

DELEGATION TO LPN/LVN is governed by the RN's judgment, state practice act, and the 5 Rights of Delegation. Understanding the LPN/LVN SCOPE OF PRACTICE is essential. LPN/LVNs CAN typically do: Administer routine oral, IM, SubQ, and topical medications to stable clients; Perform straightforward assessments (monitoring vital signs, wound assessment with documented wound) with changes reported to the RN; Insert urinary catheters; Perform selected IV tasks (varies by state — some allow LPNs to administer IV medications; others do not); Wound care per written protocol; Teaching using prepared materials to reinforce RN-initiated education. LPN/LVNs CANNOT typically do: INITIAL ADMISSION ASSESSMENT requiring comprehensive, complex nursing judgment (that's RN scope because assessment drives the care plan); DEVELOP NURSING CARE PLANS (requires professional nursing judgment); INITIAL PATIENT EDUCATION for complex new diagnoses (requires assessment of learning needs, ability to adapt teaching dynamically); IV push medications or blood administration (varies by state); Managing unstable or complex acutely ill patients independently. WHY OPTION B IS CORRECT: Administering a scheduled oral medication to a stable client is a routine, established, non-complex task well within LPN scope — the medication is known (not first dose), the client is stable, and there are no complicating factors described. The RN retains accountability for supervision and outcome monitoring.

Source: NCLEX-RN Test Plan: Safe Care — Delegation, LPN Scope

Full Q&A page →

Question 9

A nurse is preparing to administer IV vancomycin to a client. Which laboratory value must be checked BEFORE administration?

  1. Serum potassium
  2. Serum creatinine and/or BUN — vancomycin is nephrotoxic (kidney-toxic) and is renally cleared; impaired renal function causes drug accumulation and increased toxicity risk; dosing is adjusted based on renal function and monitored via trough serum levels ✓
  3. Hemoglobin
  4. Serum glucose
▶ Show full explanation

VANCOMYCIN is a glycopeptide antibiotic used primarily for MRSA and other gram-positive organisms. It is one of the most important antibiotics to monitor because of significant toxicity risks. NEPHROTOXICITY — RENAL MONITORING: Vancomycin is eliminated by the kidneys; impaired renal function causes accumulation; creatinine and BUN must be checked before initiation and monitored every 2-3 days during therapy; dosing must be adjusted for renal impairment (reduced dose or extended dosing interval based on creatinine clearance); signs of nephrotoxicity: rising creatinine, decreased urine output. OTOTOXICITY — HEARING: Vancomycin can damage hearing (both cochlear and vestibular toxicity); more common with high levels or prolonged therapy; warn clients to report ringing in ears (tinnitus), hearing changes, dizziness. SERUM VANCOMYCIN LEVELS — TROUGH MONITORING: Trough level is drawn just before the next scheduled dose (within 30 minutes); current AUC (area under the curve) monitoring is the preferred approach in many institutions but trough remains common; traditional therapeutic trough: 15-20 mcg/mL for serious infections; levels above 20 mcg/mL significantly increase nephrotoxicity risk. 'RED MAN SYNDROME': Not an allergy but a rate-related reaction — flushing, erythema, and hypotension from too-rapid infusion; prevented by infusing over at least 60 minutes (often 60-90 minutes for 500-1000mg doses); if it occurs, slow or stop infusion, give diphenhydramine. NURSING ROLE: Check renal function labs before each course and monitor during; schedule trough draws correctly; administer slowly; educate client on side effects to report.

Source: NCLEX-RN Test Plan: Safe Care — Vancomycin Monitoring

Full Q&A page →

Question 10

A client develops a sudden onset of chest pain, shortness of breath, and hypotension after a central line placement. The nurse suspects a pneumothorax. What is the PRIORITY action?

  1. Obtain a portable chest X-ray before notifying the physician
  2. Stay with the client, call for immediate help (activate rapid response team or code team), administer supplemental oxygen, and notify the physician immediately — this is a life-threatening emergency that cannot wait for X-ray confirmation ✓
  3. Have the client take deep breaths to re-expand the lung
  4. Increase IV fluid rate
▶ Show full explanation

TENSION PNEUMOTHORAX is a potentially fatal complication of central line placement (and other thoracic procedures). It occurs when air enters the pleural space and cannot escape, progressively compressing the lung and eventually shifting the mediastinum (tension). CLINICAL PRESENTATION: Sudden chest pain; acute dyspnea; hypotension; decreased or absent breath sounds on one side; tracheal deviation (late sign, shifting away from the affected side); hypoxia; tachycardia progressing to cardiovascular collapse. PRIORITY ACTIONS — TIME IS CRITICAL: (1) STAY WITH CLIENT — do not leave; (2) ACTIVATE RAPID RESPONSE or code team per facility protocol; (3) SUPPLEMENTAL OXYGEN — high-flow via non-rebreather mask; (4) CALL PHYSICIAN STAT — tension pneumothorax requires immediate needle decompression (needle thoracostomy) by the physician, followed by chest tube; (5) PREPARE FOR EMERGENCY INTERVENTION — anticipate needle decompression and chest tube setup; (6) CONTINUOUS MONITORING — SpO2, blood pressure, respiratory status every few minutes. WHY NOT WAIT FOR X-RAY: Tension pneumothorax is a clinical diagnosis in an emergency — waiting for X-ray while the client decompensates can result in cardiac arrest. Clinical findings of tension pneumothorax require immediate treatment. The physician will typically perform needle decompression based on clinical presentation before X-ray confirmation. NURSE'S ROLE: The nurse cannot perform needle thoracostomy — that is a physician/advanced practice procedure — but the nurse's rapid recognition, notification, and preparation are what determine the outcome.

Source: NCLEX-RN Test Plan: Safe Care — Emergency Response, Pneumothorax

Full Q&A page →

Standard precautions apply to all HIV patients: HIV is not transmitted by casual contact, respiratory droplets, or food — standard precautions (gloves for blood/body fluid contact) are sufficient. HIV patients are placed in protective (reverse) isolation when severely immunocompromised to protect them FROM infections from staff and visitors — not to protect others FROM the patient.

Ready to practice all 25 questions?

The full practice test covers every topic area — practice mode with explanations or timed mock exam mode.

Take the RN: Safe and Effective Care Environment practice test →

Or read the NCLEX exam guide for format, scoring, and study tips.