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A
'You should feel better within 24-48 hours.'
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B
'Most people notice improvement in mood within 2-4 weeks, though full therapeutic effect typically takes 4-8 weeks — some side effects may appear before mood improvement'
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C
'SSRIs work differently for everyone — some people never respond'
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D
'You will feel better immediately after the first dose'
Why this is the answer
SSRI ONSET OF ACTION: SSRIs do not produce immediate mood improvement. TIMELINE: Initial effects (sleep improvement, anxiety reduction, energy): sometimes within 1-2 weeks; Mood improvement: typically 2-4 weeks; Full therapeutic effect: 4-8 weeks at therapeutic dose; IMPORTANT: Some side effects (nausea, headache, insomnia, sexual dysfunction) may appear BEFORE mood improvement — clients must be warned or they often discontinue early assuming it's 'not working'; CLINICAL SIGNIFICANCE: The most dangerous period for suicidal ideation in depression treatment is often when the client has enough energy to act but mood has not yet improved (within the first 1-4 weeks) — requires close monitoring during this period; EDUCATION: Never stop suddenly — taper under provider guidance to avoid discontinuation syndrome.
Source: NCLEX-PN PS — Psychopharmacology, SSRI Timeline