NCLEX · Study Guide

NCLEX-RN Psychiatric Medications — Lithium, MAOIs, Antipsychotics, and Monitoring

Psychiatric medication questions test the dangerous adverse effects and the monitoring that prevents them. These questions cover lithium toxicity, MAOI dietary restrictions, antipsychotic EPS, and the critical safety parameters for each drug class.

Psychiatric medications carry serious risks that the NCLEX-RN tests directly. The exam focuses on the monitoring and adverse effects: lithium's narrow therapeutic range and toxicity signs, MAOI tyramine reactions and hypertensive crisis, and the extrapyramidal symptoms of antipsychotics.

Source

How these questions were selected

These 10 questions were curated by the 247SimpleTests Editorial Team from our RN: Psychosocial Integrity practice bank. Each was selected because it covers a concept that appears frequently on the real exam and that many candidates find difficult on their first attempt. The full practice test has 25 questions — work through all of them once you've reviewed this guide.

The questions

Question 1

A 45-year-old client is admitted for alcohol withdrawal monitoring. Which scale is used to standardise assessment and guide benzodiazepine dosing in alcohol withdrawal?

  1. PHQ-9
  2. Glasgow Coma Scale
  3. Clinical Institute Withdrawal Assessment for Alcohol, revised (CIWA-Ar) — a 10-item scale assessing autonomic symptoms (HR, BP), tremor, diaphoresis, agitation, and hallucinations; scores guide symptom-triggered benzodiazepine administration (e.g., lorazepam if CIWA-Ar > 8-10) ✓
  4. CAGE questionnaire
▶ Show full explanation

CIWA-Ar SCALE: THE STANDARD: Most commonly used validated tool for alcohol withdrawal monitoring; ITEMS: Nausea/vomiting; tremor; diaphoresis; anxiety; agitation; tactile disturbances (formication); auditory disturbances; visual disturbances; headache; orientation/clouding; SCORING: 0-67 total; INTERPRETATION: <10: Mild — monitoring, no medication unless symptoms progress; 10-15: Moderate — consider benzodiazepine; >15: Severe — benzodiazepine required; >20: Risk for delirium tremens; SYMPTOM-TRIGGERED vs FIXED SCHEDULE: CIWA-Ar allows symptom-triggered dosing — only administer benzodiazepine when score exceeds threshold (reduces total benzodiazepine dose, shortens withdrawal duration, improves safety vs fixed schedule); NURSING ROLE: Assess CIWA-Ar every 1-4 hours per protocol; administer PRN benzodiazepines per orders when threshold reached; monitor vital signs; ensure IV access; COMPARE: CAGE questionnaire = screening tool (Cut-down, Annoyed, Guilty, Eye-opener) for AUD history — not for acute withdrawal monitoring.

Source: NCLEX-RN Psychosocial — Substance Use, CIWA-Ar Alcohol Withdrawal Monitoring

Full Q&A page →

Question 2

A client is prescribed an MAOI (monoamine oxidase inhibitor) antidepressant. Which dietary teaching is essential?

  1. Increase protein intake
  2. Avoid foods high in tyramine (aged cheeses, cured meats, fermented foods, draft beer, soy sauce) — combining MAOIs with tyramine can cause a hypertensive crisis, a life-threatening emergency ✓
  3. Avoid all carbohydrates
  4. Drink grapefruit juice daily
▶ Show full explanation

MAOI DIETARY RESTRICTIONS — TYRAMINE: MAOIs (phenelzine, tranylcypromine, isocarboxazid, selegiline) inhibit the enzyme that breaks down tyramine; consuming tyramine-rich foods while on an MAOI causes a dangerous spike in blood pressure (HYPERTENSIVE CRISIS). TYRAMINE-RICH FOODS TO AVOID: Aged cheeses; cured/smoked/processed meats (salami, pepperoni); fermented foods (sauerkraut, kimchi, miso); draft/tap beer; red wine; soy sauce; fava beans; overripe fruits; aged/fermented anything; HYPERTENSIVE CRISIS SIGNS: Severe occipital headache, palpitations, neck stiffness, nausea/vomiting, sweating, severe hypertension — MEDICAL EMERGENCY; DRUG INTERACTIONS: MAOIs interact dangerously with many drugs (SSRIs, sympathomimetics, opioids like meperidine) — risk of serotonin syndrome and hypertensive crisis; require washout periods between MAOIs and other antidepressants; PATIENT EDUCATION: Strict dietary compliance, avoid OTC cold/decongestant medications, report severe headache immediately; nursing role: thorough dietary and drug-interaction teaching, monitor for hypertensive crisis, ensure the client understands the serious consequences of dietary non-compliance.

Source: NCLEX-RN Psychosocial — Psychopharmacology, MAOI Tyramine

Full Q&A page →

Question 3

A bereaved spouse says: 'It's been 14 months since my wife died and I still cry every day — something must be wrong with me.' What is the most appropriate nursing response?

  1. 'You're right, 14 months is too long — you should seek medication'
  2. 'Grief has no set timeline. While intense acute grief typically evolves over the first year, it is normal to continue experiencing sadness and missing someone you loved deeply. The question is whether grief is impairing your ability to function in daily life' ✓
  3. 'By now you should be over it'
  4. 'You need psychiatric evaluation immediately'
▶ Show full explanation

COMPLICATED GRIEF vs NORMAL GRIEF: NORMAL GRIEF: Varies enormously between individuals; no set timeline; acute phase most intense first year; grief does not end — it transforms; sadness and missing the deceased indefinitely is NORMAL; COMPLICATED GRIEF (Prolonged Grief Disorder — DSM-5 2022): Persisting intense yearning; rumination about the deceased; emotional pain; difficulty accepting the death; feeling meaningless; social withdrawal — ALL still significantly present beyond 12 months (6 months for children); NURSING ASSESSMENT FOCUS: Is the person able to function (work, relationships, self-care)? Are they eating and sleeping? Are they experiencing suicidal ideation? Do they have social support?; THERAPEUTIC RESPONSE: Validate that grief is not a schedule; normalise ongoing sadness; assess for functioning and red flags; provide information about grief support resources; THE WRONG RESPONSES: Giving a timeline to 'be over it'; immediately pathologising normal grief; reassuring without assessment; INTERVENTION: Complicated grief may benefit from specialised Complicated Grief Treatment (CGT) — evidence-based therapy.

Source: NCLEX-RN Psychosocial — Grief, Normal vs Prolonged Grief Disorder

Full Q&A page →

Question 4

A client with terminal cancer says: 'I don't want my family to know how bad the pain is — they worry so much.' What does the nurse do?

  1. Honour the request completely and tell the family nothing
  2. Respect the client's decision about disclosure while ensuring their pain is adequately managed — explore the client's concerns about the family's emotional response; offer strategies for pain control that meet the client's needs; remind the client of available support; document the client's preferences ✓
  3. Tell the family everything immediately
  4. Insist the family must know
▶ Show full explanation

PATIENT CONFIDENTIALITY AND PAIN MANAGEMENT: PATIENT AUTONOMY: The client has the right to control what medical information is shared with family — even at end of life; confidentiality does not end when prognosis is terminal; COMPETING OBLIGATION: The nurse also has an obligation to ensure adequate pain management — if the client is suffering in silence, that is a care quality issue; THERAPEUTIC APPROACH: Explore the client's concern ('Tell me more about what you're worried about when your family sees your pain'); problem-solve alternatives ('Is there a way we can manage your pain that wouldn't worry them as much?'); address the underlying fear (burden, family distress) rather than just the surface request; ENSURE ADEQUATE PAIN CONTROL: The request not to tell family does not mean accepting inadequate pain management — work with the client to address pain within their disclosure preferences; DOCUMENTATION: Document the client's expressed wishes about information sharing in the medical record; ETHICAL BALANCE: Patient autonomy is primary; the nurse advocates for the client's wellbeing while respecting their choices.

Source: NCLEX-RN Psychosocial — End of Life, Pain Disclosure and Family Communication

Full Q&A page →

Question 5

A teenager with a new type 1 diabetes diagnosis says: 'I don't care about this stupid disease — it won't change anything.' What does the nurse recognise?

  1. The teenager is medically compliant and healthy
  2. This statement may indicate denial or minimisation as a coping mechanism — adolescents with new chronic illness diagnoses often use denial to manage the psychological threat; the nurse should explore the statement without confrontation ✓
  3. The teenager is ready for discharge
  4. This is normal and requires no response
▶ Show full explanation

ADOLESCENT COPING WITH CHRONIC ILLNESS: DEVELOPMENTAL CONTEXT: Adolescents are establishing identity and peer belonging — a diagnosis of a chronic, visible disease (requiring injections, diet management, medical equipment) threatens both; denial and minimisation protect against the full psychological weight of the diagnosis; THERAPEUTIC APPROACH: Do NOT confront denial aggressively — this triggers defensiveness and shuts down communication; EXPLORE: 'It sounds like this has a lot to manage. What parts feel most overwhelming?'; 'What questions do you have about how this affects your daily life?'; ASSESS: Is the denial preventing essential self-care (not testing blood sugar, not giving insulin)? If so, it moves from adaptive to dangerous; EDUCATION APPROACH: Start with the client's concerns and questions rather than a lecture; involve the client in care planning; connect with peer support (other teens with T1DM); family involvement as appropriate; LONG-TERM: Adolescent non-compliance is the highest-risk period for T1DM complications — therapeutic relationship that doesn't alienate is critical.

Source: NCLEX-RN Psychosocial — Therapeutic Communication, Adolescent Denial of Chronic Illness

Full Q&A page →

Question 6

What is the most effective response if a nurse suspects a colleague is impaired at work?

  1. Ignore it
  2. Report concerns through proper channels — typically to charge nurse or supervisor; protects patients and the colleague who needs intervention; mandatory in many state nurse practice acts; impaired nurse programs offer recovery support ✓
  3. Confront the colleague publicly
  4. Wait for someone else
▶ Show full explanation

Nurses have an ethical and (in most states) legal duty to report suspected impairment of colleagues. The behavior may be substance use, mental health issues, or medical conditions affecting function. Why report: (1) Patient safety — impaired nurses can harm patients through errors, missed observations, poor judgment; (2) Colleague's welfare — early intervention enables recovery; ignoring enables progression of disease; (3) Profession's integrity — nursing's trust depends on accountability; (4) Mandatory in many states — nurse practice acts require reporting; failure to report can result in nurse's own license discipline. Signs of impairment: (1) Behavior changes — mood swings, isolation, irritability; (2) Performance issues — errors, missed assignments, falling asleep; (3) Physical signs — slurred speech, unsteady gait, dilated/constricted pupils, smell of alcohol; (4) Medication discrepancies — missing controlled substances, frequent waste, unusual patient pain complaints (when nurse is involved); (5) Working extra shifts or unusual hours (access to medications). What to do: (1) Document specific observations factually; (2) Report to charge nurse or nursing supervisor — proper chain of command; (3) Do not confront the colleague yourself or accuse publicly; (4) Maintain confidentiality; (5) Cooperate with subsequent investigation. Outcomes: investigation, drug testing if indicated, intervention if confirmed; many states have alternative-to-discipline programs (peer assistance programs) that allow recovery while licenses are maintained under monitoring. Punitive responses harm individuals and discourage future reporting. Nurses in recovery often return to practice successfully with proper support.

Source: NCLEX-RN, Substance Use — Impaired Colleague

Full Q&A page →

Question 7

What are healthy versus unhealthy coping mechanisms?

  1. All coping is healthy
  2. Healthy: exercise, social support, problem-solving, relaxation techniques, hobbies, professional help. Unhealthy: substance use, social isolation, denial, aggression, self-harm, overeating/restriction, excessive screen time, avoidance ✓
  3. All coping is unhealthy
  4. Coping is unnecessary
▶ Show full explanation

Coping mechanisms are strategies used to manage stress, emotions, and difficult situations. Healthy (adaptive) coping: (1) Problem-focused — addressing the stressor: planning, seeking information, taking action; (2) Emotion-focused (used when problem can't be changed) — acceptance, emotional support, positive reframing; (3) Physical strategies — exercise, sufficient sleep, healthy eating; (4) Social — talking with trusted people, support groups, professional therapy; (5) Cognitive — mindfulness, meditation, journaling, positive self-talk, cognitive restructuring; (6) Behavioral — engaging in hobbies and meaningful activities, creative expression, time in nature; (7) Spiritual — prayer, meditation, attending religious services if part of one's tradition; (8) Self-care — boundaries, time off, relaxation, pleasure activities; (9) Professional help when needed — therapy, counseling, support groups. Unhealthy (maladaptive) coping: (1) Substance use — alcohol, drugs, nicotine to numb feelings; (2) Behavioral excesses — overeating, gambling, shopping, excessive screen time, compulsive sexual behavior; (3) Restriction — undereating, excessive exercise; (4) Self-harm — cutting, burning, hitting self; (5) Aggression — verbal or physical toward others; (6) Avoidance — denial, isolation, sleeping excessively to avoid; (7) Dependence — clinging behavior, excessive reassurance-seeking; (8) Workaholism — using work to avoid feelings. Nursing role: (1) Assess coping strategies clients use; (2) Reinforce healthy strategies; (3) Education about unhealthy patterns; (4) Skills training (relaxation, mindfulness, problem-solving); (5) Refer to therapy when patterns are entrenched. Personal coping: nurses experience stress and benefit from the same strategies; self-care prevents burnout and compassion fatigue.

Source: NCLEX-RN, Coping — Healthy vs Unhealthy

Full Q&A page →

Question 8

What is 'cultural competence' in nursing care?

  1. Knowing one's own culture
  2. The ability to deliver care that recognizes, respects, and accommodates the cultural beliefs, values, practices, and needs of patients from diverse backgrounds — without stereotyping; requires self-awareness, knowledge, skill, and ongoing learning ✓
  3. Treating everyone identically
  4. Only relevant for some patients
▶ Show full explanation

Cultural competence is an essential nursing capability in increasingly diverse healthcare environments. Components: (1) Self-awareness — recognizing one's own cultural background, biases, and assumptions; (2) Cultural knowledge — understanding common health beliefs, practices, communication styles, and family structures of different groups (while avoiding stereotyping); (3) Cultural skills — applying culturally responsive assessment and intervention; (4) Cultural encounters — meaningful interaction with diverse individuals; (5) Cultural desire — genuine motivation to provide equitable care. Common areas of cultural variation: (1) Communication styles — direct vs indirect, eye contact norms, comfort with silence, gender norms, decision-making (individual vs family); (2) Health beliefs — disease causation (germ theory vs spiritual/balance), preferred treatments (Western vs traditional), prevention practices, role of healers; (3) Dietary practices — religious restrictions (kosher, halal), preferences, food meanings; (4) Family roles — who makes decisions, who provides care, gender roles, elder respect; (5) Personal space and touch — varies significantly; (6) Time orientation — present vs future; (7) Religious/spiritual practices affecting care — prayer times, modesty requirements, end-of-life rituals, blood transfusions, autopsy, organ donation; (8) Pain expression — stoic vs expressive; (9) Modesty — body exposure, same-gender providers. Cultural humility (alternative concept): lifelong learning, acknowledging power imbalances, partnering with patient and family. Avoid assumptions: ask patient about their preferences rather than assuming based on group. Use professional interpreters for non-English speakers (not family members, not staff). Provide culturally appropriate health information. The goal: equitable, respectful, effective care for every individual.

Source: NCLEX-RN, Psychosocial — Cultural Competence

Full Q&A page →

Question 9

What is the appropriate approach to spiritual care in nursing?

  1. Always avoid religious topics
  2. Assess spiritual needs as part of holistic care; respect the patient's beliefs whether or not they match the nurse's; facilitate spiritual practices the patient values; refer to chaplaincy or the patient's clergy; do not impose one's own beliefs ✓
  3. Promote nurse's religion
  4. Pray with every patient
▶ Show full explanation

Spiritual care is part of holistic nursing — recognizing that spiritual well-being affects physical and mental health. Spirituality includes religious beliefs but extends beyond — meaning, purpose, connection, transcendence, values. Spiritual assessment: (1) Faith/Beliefs — what is important to you? do you have spiritual or religious beliefs that affect your health care? (2) Importance — how do these beliefs influence how you take care of yourself? (3) Community — are you part of a religious or spiritual community? (4) Address — how would you like me to address these issues in your care? (FICA tool — Faith, Importance, Community, Address). HOPE tool — Sources of Hope, Organized religion, Personal spirituality and practices, Effects on care. Nursing interventions: (1) Active listening to spiritual concerns; (2) Facilitate practices the patient values — quiet time for prayer or meditation, prayer rugs, religious texts available, religious dietary needs, sacraments, ritual objects; (3) Refer to chaplaincy services — most hospitals have multifaith chaplains available 24/7; (4) Coordinate with patient's own clergy; (5) Be present during difficult times; (6) Respect rituals around death — last rites, washing the body, family time. What the nurse avoids: (1) Imposing personal beliefs on patients; (2) Proselytizing; (3) Judging beliefs that differ from one's own; (4) Praying with patients unless they request and the nurse is comfortable; (5) Engaging in theological discussions outside one's expertise (refer to chaplaincy). Spiritual distress: when illness or loss disrupts beliefs/connection — manifests as questioning faith, feeling abandoned by God, fear of death, meaning crisis. Address with presence, reflection, referral to chaplaincy. Nurses respect atheist, agnostic, and secular humanist patients with the same regard.

Source: NCLEX-RN, Psychosocial — Spiritual Care

Full Q&A page →

Question 10

What is post-traumatic stress disorder (PTSD) and what are its key symptoms?

  1. Brief sadness after stress
  2. Mental health disorder following exposure to actual or threatened death, serious injury, or sexual violence; symptoms include intrusion (flashbacks, nightmares), avoidance, negative alterations in cognition/mood, and arousal/reactivity — lasting >1 month ✓
  3. Only physical injury
  4. Brief reaction
▶ Show full explanation

PTSD (DSM-5) develops in some individuals exposed to trauma — actual or threatened death, serious injury, or sexual violence. Exposure types: directly experiencing, witnessing, learning about (close family/friend), or repeated/extreme exposure (first responders). Symptoms persist >1 month and cause significant distress/impairment. Four symptom clusters (1+ from each cluster required): (1) INTRUSION — recurrent, involuntary memories; nightmares; flashbacks (dissociative reactions where the person feels they are re-experiencing); intense psychological distress at trauma cues; physiological reactivity to trauma cues. (2) AVOIDANCE — efforts to avoid trauma-related memories/thoughts/feelings; efforts to avoid external reminders (people, places, situations). (3) NEGATIVE ALTERATIONS in cognition/mood — inability to remember important aspects of trauma; persistent negative beliefs ('I'm bad,' 'No one can be trusted'); distorted blame; persistent negative emotional state; diminished interest in activities; detachment; inability to experience positive emotions. (4) AROUSAL AND REACTIVITY — irritability/anger outbursts; reckless or self-destructive behavior; hypervigilance; exaggerated startle; concentration problems; sleep disturbance. Subtypes: with dissociative symptoms; with delayed expression (symptoms develop 6+ months later). Acute Stress Disorder: similar to PTSD but lasts 3 days to 1 month. Treatment: (1) Trauma-focused therapy — Prolonged Exposure (PE), Cognitive Processing Therapy (CPT), EMDR (Eye Movement Desensitization and Reprocessing) — gold standard treatments; (2) Medications — SSRIs (sertraline, paroxetine FDA-approved); SNRIs (venlafaxine); prazosin for nightmares; (3) Group therapy; (4) Mind-body practices — yoga, mindfulness; (5) Service animals. Nursing care: trauma-informed approach throughout; recognize triggers; safety; therapeutic alliance.

Source: NCLEX-RN, Mental Health — PTSD

Full Q&A page →

The psychiatric medication danger list: Lithium → narrow therapeutic range (0.6-1.2 mEq/L), toxicity causes tremor/confusion/GI symptoms, maintain consistent sodium and fluids; MAOIs → avoid tyramine (aged cheese, cured meat, fermented foods) or risk hypertensive crisis; Antipsychotics → watch for EPS, tardive dyskinesia, and the emergency of neuroleptic malignant syndrome (high fever, rigidity, altered consciousness); Clozapine → weekly CBC for agranulocytosis.

Ready to practice all 25 questions?

The full practice test covers every topic area — practice mode with explanations or timed mock exam mode.

Take the RN: Psychosocial Integrity practice test →

Or read the NCLEX exam guide for format, scoring, and study tips.