NCLEX · Mental Health Disorders

A client is prescribed an MAOI (monoamine oxidase inhibitor) antidepressant. Which dietary teaching is essential?

Correct answer

Avoid foods high in tyramine (aged cheeses, cured meats, fermented foods, draft beer, soy sauce) — combining MAOIs with tyramine can cause a hypertensive crisis, a life-threatening emergency

  1. A Increase protein intake
  2. B Avoid foods high in tyramine (aged cheeses, cured meats, fermented foods, draft beer, soy sauce) — combining MAOIs with tyramine can cause a hypertensive crisis, a life-threatening emergency
  3. C Avoid all carbohydrates
  4. D Drink grapefruit juice daily

Why this is the answer

MAOI DIETARY RESTRICTIONS — TYRAMINE: MAOIs (phenelzine, tranylcypromine, isocarboxazid, selegiline) inhibit the enzyme that breaks down tyramine; consuming tyramine-rich foods while on an MAOI causes a dangerous spike in blood pressure (HYPERTENSIVE CRISIS). TYRAMINE-RICH FOODS TO AVOID: Aged cheeses; cured/smoked/processed meats (salami, pepperoni); fermented foods (sauerkraut, kimchi, miso); draft/tap beer; red wine; soy sauce; fava beans; overripe fruits; aged/fermented anything; HYPERTENSIVE CRISIS SIGNS: Severe occipital headache, palpitations, neck stiffness, nausea/vomiting, sweating, severe hypertension — MEDICAL EMERGENCY; DRUG INTERACTIONS: MAOIs interact dangerously with many drugs (SSRIs, sympathomimetics, opioids like meperidine) — risk of serotonin syndrome and hypertensive crisis; require washout periods between MAOIs and other antidepressants; PATIENT EDUCATION: Strict dietary compliance, avoid OTC cold/decongestant medications, report severe headache immediately; nursing role: thorough dietary and drug-interaction teaching, monitor for hypertensive crisis, ensure the client understands the serious consequences of dietary non-compliance.
Source: NCLEX-RN Psychosocial — Psychopharmacology, MAOI Tyramine

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