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A
The cuticle only
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B
The cortex (after the cuticle is opened)
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C
The medulla only
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D
The scalp
Why this is the answer
Permanent haircolor works mainly within the cortex of the hair. The product (typically with a developer) raises the cuticle so the color can penetrate into the cortex, where it develops and becomes trapped, producing long-lasting color. This is why permanent color is a chemical change and grows out rather than washing away quickly. Temporary and some semi-permanent colors deposit more on the surface/cuticle. Connecting where color works (the cortex) to the structure of the hair shaft is standard color theory on the exam.
Source: Hair Care — Where Color Works